Figure 2. Schematic representation of the modular architecture of PLD2 with separation of activities.

The PX and PH protein domains at the regulatory N-terminus are putatively responsible for the newly described GEF activity of PLD2, which binds to the small GTPase Rac2 through two “CRIB” domains in PLD2 and mediates the GDP/GTP exchange. On the other hand, two conserved HKD domains are responsible for the lipase activity and conversion of PC into PA.