. 2012 Sep;92(3):445–459. doi: 10.1189/jlb.0212052

Table 1. Surface marker, tissue distribution, and transcriptional regulators of murine DC subsets.

DC subset	Surface markers	Tissue distribution	Transcription factor(s) required^a	References
pDC	CD11c^loCD11b⁻B220⁺PDCA-1⁺ SiglecH⁺	Lymphoid/nonlymphoid	E2-2, Gfi1, Ikaros, IRF4, IRF8, PU.1, STAT3	[99, 100, 102–104, 106, 108, 238]
cDC
CD8α⁺	CD11c^hiMHCII⁺CD11b^loCD4⁻ CD8α⁺	Lymphoid	Batf3, Gfi1, Id2, Ikaros, IRF8, PU.1	[100, 102, 107, 108, 113, 215, 239, 240]
CD8α⁻	CD11c^hiMHCII⁺CD11b^hiCD8α⁻ CD4⁺ or CD4⁻	Lymphoid	Gfi1, IRF2, IRF4, PU.1, RelB, RBP-J	[100, 108, 112, 119–122, 147]
CD103⁺	CD11c⁺MHCII⁺CD11b^loCD103⁺	Nonlymphoid; lymph nodes; lamina propria^b	Batf3, IRF8, Id2	[116, 118]
CD103⁻	CD11c⁺MHCII⁺CD11b^hiCD103⁻	Nonlymphoid; lamina propria^b	Unknown	[117]
LC	Langerin⁺MHCII^loCD11b⁺ CD207^hiCD103⁻	Epidermis	Id2, IRF2, Runx3	[113, 123, 147]

While PU.1 function has not been determined in all DC subsets listed, it is expected to be required due to its role in mediating macrophage and DC development.

In mouse lamina propria, the CD103⁺ and CD103⁻ DCs are further characterized based on their expression of M-CSFR and CX₃CR1, including MHCII^hiCD11c^hiCD103⁺CD11b⁺ CX₃CR1⁻M-CSFR^lo, MHCII^hiCD11c^hiCD103⁻CD11b⁺CX₃CR1⁺M-CSFR^hi, MHCII^hiCD11c^hiCD103⁺CD11b⁻CX₃CR1⁻M-CSFR^lo, and MHCII^hiCD11c^loCD103⁻CD11b⁺CX₃CR1⁺M-CSFR^hi [117].