Table 2. Surface marker, tissue distribution, and transcriptional regulators of human DC subsets.
DC subset | Surface markers | Tissue distribution | Transcription factor(s) | Referencesa |
---|---|---|---|---|
pDC | HLA-DR+CD11c−BDCA-2+ BDCA-4+CD123+ | Blood, tonsil, lymph nodes | E2-2, GATA-2, IRF8, SpiB, PU.1 | [99, 216, 221–223, 237] |
DC | ||||
CD1c+ (BDCA-1+) | HLA-DR+CD11c+CD11b+ CD1c+ | Blood, tonsil, lymph nodes | GATA-2, IRF8 | [216, 221–223] |
CD141+ (BDCA-3+) | HLA-DR+CD11c+CD11b− CD141+XCR1+CLEC9A+ | Blood, tonsil, lymph nodes | GATA-2, IRF8 | [216, 221–223] |
CD103+ | DC-LAMP+CD103+ | Mesenteric lymph nodes | Unknown | NA |
CD1a+ | CD11c+CD1a+CD14− | Skin, lymph nodes | GATA-2, STAT5 | [157, 221–223] |
CD14+ | CD11c+ CD14+ CD1a− | Skin, lymph nodes | GATA-2 | [221–223] |
LC | CD11c+EpCAM+ | Skin, skin-draining lymph nodes | Unknown | NA |
Mono/DC | ||||
CD16+ | CD11c+CD16+HLA-DR+ | Blood | GATA-2 | [221–223] |
References for transcriptional regulators are provided. References for DC subset identification and localization can be found in the text.