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Corticosterone levels in ACTH-stimulated and -unstimulated male animals. Mice were either left unstimulated or stimulated with ACTH at 1 unit (10 μg)/100 g. 11β-HSD1 KO, H6PDH KO and DKO animals display elevated levels of circulating corticosterone relative to WT levels, which is indicative of enhanced HPA axis drive. However, the mean differences between groups were not found to be statistically significant (n>4/group).
