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. Author manuscript; available in PMC: 2012 Aug 26.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2010 Mar-Apr;2(2):148–161. doi: 10.1002/wsbm.53

Figure 1. A schematic of lin-4 gene, pre-miRNA, and miRNA structure.

Figure 1

The lin-4 miRNA was mapped to a 693 bp region (depicted by a bar) within the ninth intron of F59G1.4 (not drawn to scale) [59]. Processing of the primary lin-4 transcript (pri-miRNA) by Drosha-DGCR8 liberates the pre-miRNA. Dicer processes the pre-miRNA further into a 21 nt RNA duplex. The two miRNA strands are separated by an unknown mechanism, and typically one strand is loaded into Ago to form an active RISC, whereas the other strand (passenger strand) is excluded from RISC.