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. Author manuscript; available in PMC: 2012 Aug 26.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2010 Mar-Apr;2(2):148–161. doi: 10.1002/wsbm.53

Figure 3. The miRNA silencing pathway.

Figure 3

Transcription and pri-miRNA processing in the nucleus (large circle) are depicted, as well as miRISC assembly and silencing of target mRNAs in the cytoplasm. An interaction that results in activation is denoted by a positive symbol (+); whereas a negative symbol (−) denotes inhibition. Bottom, a legend of what the symbols represent are provided (inset box). A detailed description of the pathway can be found in the text.