Table 3.

Longitudinal Changes in Gray Matter

P value*	Cluster Extent	T	Z	X	Y	Z	Region
Group x Time Interaction
0.000	195	6.33	4.73	51	−48	46	R Angular Gyrus
0.000	186	6.07	4.60	−3	−60	34	L Precuneus
0.000	323	5.75	4.45	46	4	−12	R Superior Temporal Gyrus
0.000	133	5.29	4.21	42	−6	7	R Insula
0.000	296	4.94	4.01	−50	5	−5	L Superior Temporal Gyrus
0.000	145	4.87	3.97	−38	−69	−56	L Cerebellum
0.000	121	4.61	3.81	−50	17	21	L Inferior Frontal Gyrus
0.000	292	4.44	3.71	−21	−96	3	L Occipital Pole
0.000	125	4.30	3.63	−36	−70	−39	L Cerebellum
MA-Dependence - Time 2 > Time 1
0.000	955	6.28	4.70	46	4	−12	R Superior Temporal Gyrus
0.000	256	6.27	4.70	56	−48	37	R Angular Gyrus
0.000	360	6.18	4.66	−48	3	−6	L Superior Temporal Gyrus
0.000	171	6.10	4.62	12	−75	42	R Precuneus
0.000	594	6.09	4.61	−50	14	21	L Inferior Frontal Gyrus
0.000	134	5.63	4.38	57	−43	9	R Middle Temporal Gyrus
0.000	100	5.27	4.19	−3	60	34	L Precuneus
0.000	119	5.19	4.15	42	−4	9	R Insula
0.000	105	5.18	4.14	−60	−25	−9	L Middle Temporal Gyrus
0.000	209	5.05	4.07	−46	18	−8	R Frontal Operculum
0.000	272	4.90	3.98	46	36	13	R Inferior Frontal Gyrus
0.000	143	4.64	3.83	4	51	−14	R Ventromedial Prefrontal Cortex
0.000	271	4.46	3.72	−21	−96	3	L Occipital Pole
MA-Dependence - Time 1 > Time 2
0.000	1479	7.41	5.19	−27	−76	−36	L Cerebellum
0.000	252	4.47	3.73	34	−78	−36	R Cerebellum

^*uncorrected voxel-level p-value

R, right hemisphere; L, left hemisphere