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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Inflamm Bowel Dis. 2013 Jan;19(1):174–184. doi: 10.1002/ibd.23000

Figure 6. IBD in Hb-infected EpithTg/Rag2−/− receiving adoptive transfer.

Figure 6

(A) EpithTg/Rag2−/− and EpithNtg/Rag2−/− mice were infected with Hb one week prior to adoptive transfer with 2×105 CD4+CD45RBhi cells IP. Animals were necropsied at three weeks post adoptive transfer. Rag2−/− mice receiving Hb and adoptive transfer are positive controls for disease development. Other controls received adoptive transfer only. (B) EpithTg (line 6258)/Rag2−/− mice were given Hb and adoptive transfer as in (A) and monitored for 16 weeks post adoptive transfer. Rag2−/− controls developed disease rapidly and were necropsied at 3–4 weeks post adoptive transfer. Three treatment groups in (B) show data from animals in two separate studies (# on x axis labels). Treatment groups were compared using nonparametric one way ANOVA (Kruskal-Wallis) followed by Dunn's post test comparing all treatment groups to positive (Rag2−/−+Hb+AT) control (* P<0.05, ** P<0.01, *** P<0.001).