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Spontaneous neuropathic pain requires descending modulation. (a) Single trial conditioning with RVM lidocaine selectively induced chamber preference in SNI rats. * P < 0.05 as above. (b) RVM lidocaine reversed SNI-induced allodynia. * P < 0.05 (two-factor repeated ANOVA, Student-Neuman-Keuls versus pre-drug value). Graphs represent mean ± s.e.m. (n = 6).
