Table 2.

UV-Visible-Derived Thermodynamic Parameters for the Melting of the G, 8-oxoG, and Gh-Containing Duplexes^a

Duplex	Tmb (°C)	ΔH°VH (kcal/mole)	ΔS°VH (cal/(mole•K))	ΔG°VHc (kcal/mole)	ΔTm (°C)	ΔΔH°VH (kcal/mole)	ΔΔS°VH (cal/(mole•K))	ΔΔG°VH (kcal/mole)
G	56.5 ± 0.1	111 ± 13	308 ± 30	15 ± 0.7	-	-	-	-
8-oxoG	55.2 ± 0.6	108 ± 7	307 ± 12	13 ± 0.9	−1.3	NDd	NDd	NDd
Gh	39.8 ± 0.1	80 ± 7	230 ± 15	9 ± 0.6	−16.7	−31	−78	−6

^aDNA in 10 mM sodium phosphate, 100 mM NaCl, 0.1 mM EDTA, pH 7.0.

^bT_m reported for a duplex concentration of 2.6 μM.

^cValue at 37 °C.

^dNot statistically different from G-containing duplex.