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. Author manuscript; available in PMC: 2012 Aug 26.
Published in final edited form as: Int Rev Neurobiol. 2010;91:95–128. doi: 10.1016/S0074-7742(10)91004-0

FIG. 3.

FIG. 3

Ethanol-responsive eQTL for Gabrb2. PFC S-score microarray data described in Fig. 2 was searched for Gabrb2 responses within GeneNetwork. (A) QTL tracing for GABA-A receptor subunit beta 2 (Gabrb2). The transcript abundance of this gene is being regulated in trans by loci on chromosomes 7, 13, and proximal 17. (B) The change in Gabrb2's expression induced by acute ethanol (1.8 g/kg) is significantly correlated with anxiety as measured by elevated plus maze (Yang et al., 2008). (C) Gabrb2 gene coexpression network. The ethanol response of all plotted genes correlate significantly with that of Gabrb2 (p-value ≤ 5 × 10−9).