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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Apr 1;1813(11):1965–1970. doi: 10.1016/j.bbamcr.2011.03.013

Figure 3. Analogy between p53 and FOXO activities.

Figure 3

By analogy to p53, which induces Sestrin1 and Sestrin2 transcriptionally, FOXO induces Sestrin3 transcriptionally. p53 reduces ROS and inhibits mTORC1 through the induction of Sestrin1 and 2 expression, while FOXO reduces ROS and inhibits mTORC1 through the induction of Sestrin3 expression.