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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Apr 1;1813(11):1965–1970. doi: 10.1016/j.bbamcr.2011.03.013

Figure 4. FOXO maintains cellular energy homeostasis by coordinating cellular supplies and demands.

Figure 4

Under conditions of growth factor limitation or other cellular stresses, FOXO transcription factors are activated, and inhibit the anabolic energy consuming functions of mTORC1, while activating Akt to facilitate energy producing processes. Prolonged stress conditions and activation of mTORC1 could induce autophagy (see text for details).