Table 5.
Age-specific clinical outcome of active chronic hepatitis B by HBeAg status in the natural history scenario
| HBeAg status | n | Outcome | ||||
|---|---|---|---|---|---|---|
| Age-group (years) | Cirrhosis (%) | Decompensated Cirrhosis (%) | HCC (%) | Liver transplant (%) | Death (%) | |
| HBeAg+ | ||||||
| <15 | 90,621 | 819 (1) | 863 (1) | 1,234 (1) | 503 (0,5) | 2,574 (3) |
| 15–24 | 91,504 | 833 (1) | 877 (1) | 1,257 (1) | 512 (0,5) | 2,617 (3) |
| 25–34 | 113,892 | 35,401 (31) | 12,082 (11) | 8,461 (7) | 5,776 (5) | 27,276 (24) |
| 35–44 | 35,222 | 10,966 (31) | 3,694 (11) | 2,561 (7) | 1,769 (5) | 8,316 (24) |
| 45–54 | 11,923 | 3,783 (32) | 1,741 (15) | 1,050 (9) | 825 (7) | 3,842 (32) |
| 55–64 | 5,070 | 1,630 (32) | 779 (16) | 452 (9) | 359 (7) | 1,689 (33) |
| 65+ | 4,565 | 1,574 (34) | 241 (5) | 206 (5) | 109 (2) | 526 (12) |
| All HBeAg+ | 352,797 | 55,006 (16) | 20,277 (6) | 15,221 (4) | 9,853 (3) | 46,840 (13) |
| HBeAg− | ||||||
| <15 | 47,586 | 424 (1) | 680 (1) | 1,153 (2) | 412 (1) | 2,465 (5) |
| 15–24 | 45,804 | 406 (1) | 657 (1) | 1,110 (2) | 400 (1) | 2,389 (5) |
| 25–34 | 132,322 | 99,242 (75) | 22,392 (17) | 26,464 (20) | 11,770 (9) | 67,484 (51) |
| 35–44 | 96,610 | 73,924 (76) | 16,424 (17) | 19,322 (20) | 8,695 (9) | 50,237 (52) |
| 45–54 | 74,353 | 54,278 (73) | 12,640 (17) | 15,614 (21) | 6,692 (9) | 39,407 (53) |
| 55–64 | 41,595 | 28,285 (68) | 7,071 (17) | 8,319 (20) | 3,744 (9) | 22,045 (53) |
| 65+ | 37,280 | 25,723 (69) | 4,846 (13) | 5,592 (15) | 2,237 (6) | 13,794 (37) |
| All HBeAg− | 475,550 | 323,374 (68) | 76,088 (16) | 90,355 (19) | 38,044 (8) | 223,509 (47) |
| Total | 828,347 | 356,189 (43) | 91,118 (11) | 99,402 (12) | 49,701 (6) | 256,788 (31) |