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Pharmacokinetic Parameters (Mean ± SD) Estimated by Noncompartment Methods After Single Subcutaneous Doses of VRS-317 in Cynomolgus Monkeys
| Dose (mg/kg) (nmol/kg) | Cmax (μg/mL) | Cmax (nM) | AUC0–∞ (μg h/mL) | AUC0–∞ (nM h) |
|---|---|---|---|---|
| 1 (8.4) | 24.8 ± 13.5 | 208 ± 114 | 2046 ± 488 | 17,190 ± 4099 |
| 5 (42) | 98.8 ± 65.2 | 830 ± 548 | 11,004 ± 3861 | 92,471 ± 32,441 |
| 25 (210) | 476 ± 236 | 3,999 ± 1985 | 87,911 ± 26,155 | 738,751 ± 219,787 |
