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. 2012 Apr 26;33(8):1261–1266. doi: 10.1002/humu.22104

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© 2012 Wiley Periodicals, Inc.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Schematic representation of the suggested role of CANT1 in proteoglycan metabolism. UDP sugars are transported into the lumen of the Golgi apparatus where sugars are transferred by specific glycosyltransferases to the growing GAG chains. UDP, the other reaction product, is hydrolysed to UMP and phosphate (P_i) by CANT1. Thanks to UDP hydrolysis, glycosyltransferase reactions are not inhibited by the product (negative feedback) and UMP is exchanged with cytosolic UDP sugars through an antiporter exchanger.