Table 3.
Brief Assessment of Cognition in Schizophrenia (BACS) Subscales and BACS Composite Score
| Week 0 raw scores |
Week 4 raw scores |
Week 8 raw scores |
Change in
Z-scores from week 0 to week 8 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Placebo (mean ± SD) |
PREG (mean ± SD) |
Placebo (mean ± SD) |
REG (mean ± SD) |
Placebo (mean ± SD) |
PREG (mean ± SD) |
Placebo (n=
9) (mean ± SD) |
PREG (n 9) (mean ± SD) |
Difference | |
| BACS subscales | |||||||||
| Verbal memory | 35.33 ± 1233 | 36.78 ±7.82 | 37.89 ± 10.5 1 | 39.00 ±712 | 37.22 ± 11.29 | 43.78 ±9.80 | 0.22 ±0.71 | 0.83 ±0.88 | 0.61 ±0.38 |
| Digit sequencing | I8.44±3.I7 | 15.78 ±3.99 | I9.56±3.I7 | 17.22 ±3.35 | 19.78 ±4.79 | 18.44 ±3.91 | 0.25 ±0.61 | 0.50 ±0.63 | 0.25 ± 0.29 |
| Token motor | 53.67 ± 16.99 | 46.44 ± 17.54 | 53.11 ± 14.18 | 55.56 ± 18.02 | 53.33 ± 11.31 | 52.22 ± 14.12 | −0.02 ± 1.04 | 0.40 ± 1.67 | 0.42 ±0.66 |
| Verbal fluency | 44.00 ± 12.43 | 45.78 ± 12.56 | 42.78 ±9.50 | 45.11 ±9.97 | 44.11 ± 11.61 | 45.22 ±7.87 | 0.01 ±0.60 | −0.05 ± 0.75 | −0.06 ±0.32 |
| Symbol coding | 36.78 ±9.32 | 36.89 ± 13.39 | 39.44 ±9.61 | 44.78 ± 11.97 | 41.22± 10.01 | 38.67 ± 13.61 | 0.27 ±0.55 | 0.11 ± 0.46 | −0.16 ± 0.24 |
| Tower of London | 14.78 ±7.89 | 13.22 ±6.26 | 15.11 ±6.68 | 15.22 ±6.06 | 15.56 + 6.15 | 16.22 ±4.94 | 0.21 ± 1.62 | 0.82 ± 1.79 | 0.61 ±0.80 |
|
Week 0
Z-scores |
Week 4
Z-scores |
Week 8
Z-scores |
Change in Z-scores from
week 0 to week 8 |
||||||
|
Placebo (mean ± SD) |
PREG (mean ± SD) |
Placebo (mean ± SD) |
PREG (mean ± SD) |
Placebo (mean ± SD) |
PREG (mean ± SD) |
Placebo (n=
9) (mean ± SD) |
PREG (n=
9) (mean ± SD) |
Difference | |
| BACS composite | −1.28 ± 0.96 | −1.54 ±0.96 | −1.14 ±0.80 | −1.04 ±0.75 | −1.06 ±0.88 | −0.93 ±0.87 | 0.22 ±0.47 | 0.60 ± 0.78 | 0.38 ±0.30 |