Table 5.

Adjusted^* hazard ratios (HR) and 95% confidence intervals (CI) for the association between serum cysteine concentration and risk of oesophageal squamous cell carcinoma and gastric cardia adenocarcinoma in the Linxian General Population Nutrition Intervention Trial cohort, stratified by sex, age, cigarette smoking and alcohol drinking.

		Oesophageal Squamous Cell Carcinoma			Gastric Cardia Adenocarcinoma
		HR	95% CI	P interaction‡	HR	95% CI	P interaction‡
Overall		0.86	0.79, 0.93		0.81	0.73, 0.89
Sex
Men		0.89	0.80, 0.98		0.82	0.73, 0.93
Women		0.82	0.72, 0.92	0.19	0.77	0.64, 0.94	0.66
Age (in years)
(<50)		0.92	0.74, 1.14		1.10	0.76, 1.58
(50–60)		0.89	0.80, 1.00		0.79	0.69, 0.91
(>60)		0.80	0.70, 0.91	0.0014	0.79	0.66, 0.94	<0.0001
Cigarette smoking ‡
Never smokers		0.91	0.73, 1.13		0.79	0.62, 1.00
Ever smokers		0.89	0.79, 1.00	0.89	0.84	0.73, 0.97	0.41
Alcohol drinking ‡
Non-drinkers		0.87	0.76, 1.00		0.77	0.66, 0.90
Drinkers		0.93	0.78, 1.10	0.94	0.86	0.69, 1.07	0.30

^*Adjusted HRs and 95% CIs in were calculated using models stratified on age and sex, with additional adjustment for continuous age variables within each stratum, cigarette smoking, alcohol drinking, BMI, serum creatinine and serum creatinine squared

^‡Cigarette and alcohol consumption were almost completely restricted to men, so data stratified by these exposures are not presented for women