Figure 9. CXCR2 inhibition suppresses spontaneous formation of benign cancers in Apc^Min/+ mice.

Apc^Min/+ mice were treated with control or CXCR1/2 pepducin from 5 weeks of age and sacrificed 50 days later. (A) Number of polyps per mouse. (B) Number of MPO⁺ cells per polyp section. (C) Representative sections of adenomas from pepducin-treated Apc^min/+ mice were immunostained with Ab against MPO (brown), counterstained with hematoxylin, and visualized by light microscopy. Clusters of MPO⁺ cells are indicated by arrows. (D) Microvessel density of adenomas from pepducin-treated Apc^Min/+ mice (n = 5–6 mice per group). **P < 0.01, ***P < 0.001, Mann-Whitney test. Box and whisker plots show median (lines within boxes), interquartile range (bounds of boxes), and upper and lower range (whiskers).