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. 2012 Aug 6;122(9):3248–3259. doi: 10.1172/JCI61216

Figure 1. Notch-activated Apcmin tumors show low-grade adenoma features.

Figure 1

Colons from 10- to 15-week-old Apcmin (APC: A, C, E, F, I, and K) and 7-week-old Vil-Cre;RosaN1+/RN1;Apcmin (APC;N1: B, D, G, H, J, and L) mice were used for histological analysis. Note that APC;N1 tumors have well-branched tubular structures (B), and more membranous β-catenin (G) and E-cadherin (H) staining with extended apical membranes (L) compared with APC tumors. Staining: H&E (A and B); E-cadherin (E-cad) (green), and β-catenin (β-cat) (red) (C, D, E, F, G, and H); E-cadherin (green) and α-catenin (red) (I and J); and E-cadherin (green) and ZO-1 (red) (K and L). N, normal tissue; T, tumor. Dotted lines indicate tumor regions. Scale bars: 50 εm.