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. 2012 Aug 6;122(9):3248–3259. doi: 10.1172/JCI61216

Figure 7. Activation of Notch signaling downregulated expression of WNT target genes in CRCLs.

Figure 7

(A and B) Real-time qRT-PCR analysis of WNT target genes (PROX1, Axin2, c-MYC, and ApcDd1) in Nrarplo/– CRCLs. SW620 and COLO205 cells were transfected with 2 εg of mock vector or ΔEN1. Levels of PROX1, Axin2, c-MYC, and ApcDd1 transcripts were measured after 48 hours. MMP2 and Nrarp were used as control and Notch target genes, respectively. β-Actin was used for normalization. Bars indicate mean + SD. *P < 0.05.