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. 2012 Aug 6;122(9):3063–3087. doi: 10.1172/JCI62636

Figure 12. Anti-Ly6C mAb treatment delays disease onset and extends survival in SOD1 mice.

Figure 12

SOD1G93A mice were treated i.p. with IgG2a (IC; 100 μg, n = 11) or 100 μg anti-6C3 mAb (n = 11) every other day starting at the onset of the disease. (A) Kaplan-Meier analysis of the probability of surviving of SOD1 as function of age. Mantel-Cox’s F-test comparison showed groups treated with 100 μg IC versus anti-Ly6C (P = 0.0097). (B) Time-to-event analysis for disease neurologic onset (neurological severity score of 2). Disease onset was significantly delayed (P = 0.0127) by anti-Ly6C (100 μg) treatment. (C) Rotarod performance of IC- and anti-Ly6C–treated groups as a function of age. Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, IC compared with anti-Ly6C groups by factorial ANOVA and Fisher’s least significant difference post hoc test. (D) Weight loss plotted for IC- and anti-Ly6C–treated groups. Data represent mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, 2-way ANOVA, Bonferroni post hoc test. (E) Duration of an early disease phase (from onset to 5% weight loss) and a later disease phase (from 5% weight loss to end stage). Data represent mean ± SEM. *P < 0.05, ***P < 0.001, 1-way ANOVA.