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. 2012 Aug 6;122(9):3063–3087. doi: 10.1172/JCI62636

Figure 15. miRNA profiling of peripheral monocytes (CD14+CD16–) in ALS patients demonstrates an inflammatory phenotype analogous to that observed in SOD1 mice.

Figure 15

(A) Quantitative nCounter expression profiling of blood-sorted CD14+CD16– monocytes for 664 miRNAs in sporadic ALS (n = 8) and relapsing-remitting MS patients (n = 8) versus healthy controls (HC; n = 8). Heatmap of uncentered Pearson correlation was used as the distance metric with average linkage for the unsupervised hierarchical clustering. P < 0.01, nonparametric Kruskal-Wallis test, significance based on Benjamini-Hochberg FDR; selected FDR limit, 0.05. (B) Bars show fold differences of significantly affected miRNAs in ALS and MS subjects versus healthy controls. miRNA expression level was normalized against the geometric mean of 5 internal housekeeping genes (ACTB, B2M, GAPDH, RPL19, RPLP0). Data represent mean ± SD. All shown miRNAs were significantly affected (P < 0.05). The complete list of P values for each significantly affected miRNA is shown in Supplemental Table 4.