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. 2012 Aug 6;122(9):3343–3354. doi: 10.1172/JCI62739

Figure 1. iNKT cell knockout and antibody-mediated depletion result in insulin resistance in lean mice.

Figure 1

For A–H, n = 10 mice per group; total 40 mice. (A) Weight gain of WT and CD1d-null mice on the LFD and HFD regimens. Mice were weighed weekly. (B) Weekly caloric intake of WT and CD1d-null mice on the LFD and HFD regimens. (C) Epididymal fat pad weights of the WT and CD1d-null mice on a LFD and HFD regimen, measured after termination. (D and E) IP-GTTs were performed after 17 weeks of LFD or HFD. Plasma glucose concentrations and the AUC for the various groups are shown. (F and G) Plasma insulin levels during the IP-GTT are shown, together with the AUC. (H and I) IP-GTT of WT and Jα18-null mice after 18 weeks of LFD. Shown are plasma glucose concentrations and the AUC for the 2 groups. n = 15 mice per group; total 30 mice. (J and K) IP-GTT of WT (Isotype) and iNKT cell–depleted (αNK1.1) WT mice. Note that this antibody also depletes NK cells. Shown are plasma glucose concentrations and the AUC for the 2 groups. n = 10 mice per group; total 20 mice. *P < 0.05.