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. Author manuscript; available in PMC: 2012 Aug 27.
Published in final edited form as: Biomaterials. 2011 Sep 3;32(35):9188–9196. doi: 10.1016/j.biomaterials.2011.08.054

Figure 3.

Figure 3

Gene expression profiles of hBMSCs on scaffolds and control surfaces at 1d and 14d revealed by microarrays. (a) Dendrogram from hierarchical cluster analysis organizing experiments by similarity. Only three treatments (marked with an asterisk) would need to be relocated to give perfect segregation by treatment in the dendrogram. (b) Heat map of relative gene expression for 831 genes identified to be significantly regulated in osteogenic controls (at least a two-fold change ‘between TCPS 1d and TCPS_OS 1d’ or ‘between TCPS 14d and TCPS_OS 14d’). Data are organized from highest up-regulation to lowest down-regulation for TCPS_OS 14d. (c) From the 831 genes shown in (b), a subset of 29 genes that are involved in skeletal system development was identified by Gene Ontology. Color scale at bottom of figure applies to (b,c) and is log2 of the ratio of fluorescence intensity to the mean value for the four TCPS 1d controls.