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. Author manuscript; available in PMC: 2012 Aug 27.
Published in final edited form as: Ann Intern Med. 2009 Dec 15;151(12):840–853. doi: 10.1059/0003-4819-151-12-200912150-00156

Table 3.

Health and economic outcomes for a city of 8.3 million individuals

Strategy Clinical attack rate Infections Deaths Deaths averted Pre-pandemic costs (millions of $) Pandemic intervention costs (millions of $) Pandemic treatment costs (millions of $) Normal healthcare expenditures (millions of $) Total Costs (millions of $) QALYs* gained Incremental cost-effectiveness ratio ($ per QALY)
Expanded adjuvanted vaccination 11% 889,908 21,882 45,941 306 203 188 1,498,439 1,501,284 404,030 10,844
Expanded antiviral prophylaxis 17% 1,429,934 35,077 32,745 455 66 301 1,496,074 1,500,339 282,329 Dominated
Stockpiled strategy 19% 1,547,648 38,061 29,761 75 34 326 1,495,532 1,499,704 258,342 8,907§
No intervention 33% 2,739,242 67,822 - - 582 1,490,164 1,497,403 - -
*

QALY = quality-adjusted life-year

Incremental to stockpiled strategy

Expanded adjuvanted vaccination provides more QALYs at a lower incremental cost effectiveness ratio

§

Incremental to no intervention