Table 3.
Strategy | Clinical attack rate | Infections | Deaths | Deaths averted | Pre-pandemic costs (millions of $) | Pandemic intervention costs (millions of $) | Pandemic treatment costs (millions of $) | Normal healthcare expenditures (millions of $) | Total Costs (millions of $) | QALYs* gained | Incremental cost-effectiveness ratio ($ per QALY) |
---|---|---|---|---|---|---|---|---|---|---|---|
Expanded adjuvanted vaccination | 11% | 889,908 | 21,882 | 45,941 | 306 | 203 | 188 | 1,498,439 | 1,501,284 | 404,030 | 10,844† |
Expanded antiviral prophylaxis | 17% | 1,429,934 | 35,077 | 32,745 | 455 | 66 | 301 | 1,496,074 | 1,500,339 | 282,329 | Dominated‡ |
Stockpiled strategy | 19% | 1,547,648 | 38,061 | 29,761 | 75 | 34 | 326 | 1,495,532 | 1,499,704 | 258,342 | 8,907§ |
No intervention | 33% | 2,739,242 | 67,822 | - | - | 582 | 1,490,164 | 1,497,403 | - | - |
QALY = quality-adjusted life-year
Incremental to stockpiled strategy
Expanded adjuvanted vaccination provides more QALYs at a lower incremental cost effectiveness ratio
Incremental to no intervention