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. Author manuscript; available in PMC: 2012 Aug 27.

Published in final edited form as: ChemMedChem. 2011 Jul 5;6(9):1593–1602. doi: 10.1002/cmdc.201100188

Locomotor hyperactivity in response to novelty of compound 3a is reduced after five days of 12.5 mgkg⁻¹ dosage (*p<0.0006 vs saline; n=9–12 per group). The locomotor response to novelty was measured in adult, male, ClockΔ19 mutant mice. All mice were housed in a standard 12:12 h light/dark cycle. The experimental group (n= 9) consisted of mice treated with 12.5 mgkg⁻¹ of 3a in 1:20 DMSO/saline, and the control group (n=12) consisted of mice treated with vehicle only. Both groups were injected once a day (i.p.) for five consecutive days prior to the test. Compound 3a: ; saline: ∎.

Inline graphic — Locomotor hyperactivity in response to novelty of compound 3a is reduced after five days of 12.5 mgkg⁻¹ dosage (*p<0.0006 vs saline; n=9–12 per group). The locomotor response to novelty was measured in adult, male, ClockΔ19 mutant mice. All mice were housed in a standard 12:12 h light/dark cycle. The experimental group (n= 9) consisted of mice treated with 12.5 mgkg⁻¹ of 3a in 1:20 DMSO/saline, and the control group (n=12) consisted of mice treated with vehicle only. Both groups were injected once a day (i.p.) for five consecutive days prior to the test. Compound 3a: ; saline: ∎.