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. 2012 Aug 27;7(8):e43963. doi: 10.1371/journal.pone.0043963

Figure 6. Effect of systemic application of MB on microglial reaction towards laser-induced axonal injury.

Figure 6

Microglial reaction towards laser-induced axonal transections within the lateral column of the spinal cord was recorded. Images are arranged such that rostral is to the left side. (A) Left images were taken immediately (5 min) after axonal transection (autofluorescence and arrow) in mutant (SOD1G93A) mice. Respective images (middle and right) were taken 30 and 60 min after injury, respectively. Upper images represent in vivo recordings of an exemplary non-treated SOD1G93A mouse. In the lower experiment, the mouse was treated with MB (10 mg oral per kg body weight per day; drug administration started at the age of 45 days). (B) Quantification of microglial response to the injured site. No significant differences in microglial reaction towards a laser-induced axonal injury were observed between non-treated and MB-treated SOD1G93A mice. Mutant mice were 60 to 90 days of age. Values are presented as mean ± SEM; no treatment: n = 9 mice, MB-treatment: n = 8.