Table 3. Replication of previously reported SNPs associated with sarcoidosis [9], [11], [25], [27].
CHR | BP(hg 19) | SNP | Gene | Alleles1 | African Americans | European Americans | PAll-Meta | Heterogeneity Test | |||||||||
MAFAA-Disc 2 | ORAA-Disc | P AA-Disc | MAFAA-Rep 2 | ORAA-Rep | P AA-Rep | PAA-Meta | MAFEA 2 | OREA | P EA | Q | I 2 (%) | ||||||
6 | 32,363,816 | rs2076530 | BTNL2 | T/C | 0.309 | 0.84 | 2.50E-01 | 0.312 | 0.80 | 2.46E-02 | 2.42E-02 | 0.434 | 0.70 | 4.19E-06 | 1.44E-06 | 0.324 | 11.3 |
6 | 32,412,480 | rs7194 | HLA-DRA | A/G | 0.424 | 1.66 | 8.73E-09 | 0.445 | 1.40 | 3.44E-04 | 1.40E-11 | 0.395 | 1.35 | 1.26E-04 | 5.28E-14 | 0.304 | 16 |
6 | 32,429,643 | rs9268853 | HLA-DRB5 | T/C | 0.214 | 0.72 | 1.16E-03 | 0.197 | 0.86 | 2.03E-01 | 7.40E-04 | 0.331 | 0.76 | 9.79E-04 | 2.39E-06 | 0.544 | 0 |
6 | 32,574,171 | rs615672 | HLA-DRB1 | C/G | 0.449 | 0.64 | 1.23E-06 | 0.438 | 0.72 | 5.50E-04 | 2.60E-09 | 0.643 | 0.81 | 8.00E-03 | 9.97E-10 | 2.00E-07 | 93.5 |
6 | 57055354 | rs1040461 | RAB23 | C/T | 0.158 | 1.13 | 3.24E-02 | 0.177 | 1.21 | 1.18E-01 | 8.04E-03 | 0.079 | 0.89 | 4.18E-01 | 1.80E-01 | 0.257 | 26.4 |
10 | 81,926,702 | rs1049550 | ANXA11 | G/A | 0.185 | 0.68 | 7.91E-04 | 0.187 | 0.88 | 2.89E-01 | 8.46E-04 | 0.409 | 0.81 | 8.33E-03 | 2.30E-05 | 0.356 | 3.2 |
Major/minor allele of AAs as the reference;
Minor allele frequency;
The odds ratio (OR) was calculated with respect to the minor allele of AAs.