Table 1. Immunophenotyping of the patient.
| Patient (normal range)A | |||||
| Patient’s age | 9 years | 13 years | 16 years | 17 years | 19 years |
| Neutrophils (×109/l) | 2.0 (1.5–3.6) | 1.0 (1.5–3.5) | ND | 0.8 (1.5–3.5) | 1.0 (1.5–3.5) |
| Eosinophils (×109/l) | 0.4 (≤0.8) | ND | ND | 0.1 (≤0.8) | 0.1 (≤0.8) |
| Monocytes (×109/l) | 0.6 (0.24–0.75)B | ND | ND | 0.5 (0.21–0.73)B | 0.6 (0.21–0.73)B |
| Total lymphocytes (counts/µl) | 4,400 (1,900–3,700)C | 900 (1,900–3,700)C | 600 (1,400–3,300)C | 700 (1,400–3,300)C | 900 (1,400–3,300)C |
| T cells | |||||
| CD3+ (%) | 48 (60–76)D | 51 (56–84)D | 73 (56–84)D | 74 (56–84)D | 62 (64–85)E |
| CD3+ counts (counts/µl) | 2112 (1,200–2,600)D | 459 (1,000–2,200)D | 438 (1,000–2,200)D | 518 (1,000–2,200)D | 558 (807–1844)E |
| CD4+ (%) | 12 (31–47)D | 18 (31–52)D | 19 (31–52)D | 27 (31–52)D | 37 (34–62)E |
| CD4+ counts (counts/µl) | 528 (650–1,500)D | 162 (530–1,300)D | 114 (530–1,300)D | 189 (530–1,300)D | 333 (460–1232)E |
| CD8+ (%) | 48 (18–35)D | 43 (18–35)D | 49 (18–35)D | 39 (18–35)D | 25 (14–42)E |
| CD8+ counts (counts/µl) | 2112 (370–1,100)D | 387 (330–920)D | 294 (330–920)D | 273 (330–920)D | 225 (187–844)E |
| CD4+CD45RA+ (%) | ND | 16 (33–66)D | 12 (33–66)D | 9 (33–66)D | 7 (58–70) |
| CD4+CD45RO+ (%) | ND | 84 (18–38)D | 88 (18–38)D | 91 (18–38)D | 93 (16–34)E |
| CD4+CD31+CD45RA+ (%) | ND | 7 (42–74)C | 7 (42–55)C | 4 (42–55)C | 3 (43–55) |
| CD8+CCR7+CD45RA+ (%) | ND | ND | ND | ND | 4 (37–50) |
| CD8+CCR7+CD45RA− (%) | ND | ND | ND | ND | 0.4 (6–16) |
| CD8+CCR7−CD45RA+ (%) | ND | ND | ND | ND | 71 (8–20) |
| CD8+CCR7−CD45RA− (%) | ND | ND | ND | ND | 24 (24–37) |
| TcRγδ (%) (2–8A) | ND | 13 | ND | ND | ND |
| B cells | |||||
| CD19+ (%) | 9 (13–27)D | 14 (6–23)D | 9 (6–23)D | 11 (6–23)D | 10 (6–17)E |
| CD27+CD19+ (%) (>15A) | ND | ND | 27 | ND | 30 |
| NK cells | |||||
| CD56+CD3+ (%) | ND | 12 | 13 | ND | ND |
| CD56+CD3− (%) | ND | 28 (6–27)F | 14 (6–27)F | ND | ND |
| CD16+CD56+ (%) | ND | ND | ND | 16 (3–22) | 22 (3–22) |
A
Normal ranges were obtained from internal laboratory controls (N = 10) unless specified otherwise.
B
normal ranges from the work of Lugada et al. [47].
C
normal ranges taken from the work of Nehme et al. [30].
D
normal ranges taken from the work of Shearer et al. [48].
E
normal ranges taken from the work of Bisset et al. [49].
F
normal ranges taken from the work of Eidenscheck et al. [50].