Table 2. Clinical characteristics of GBS patients associated with presence IgM and/or IgG antibodies in serum to the gangliosides GM1, GD1a and GQ1b*.
Serum IgM and/or IgG antibodies to GM1, GD1a and/or GQ1b | ||||
Positive (N = 54) | Negative (N = 43) | Odds ratio (95% CI) | P-value† | |
Clinical features | ||||
Age (median) | 18 (2–52) | 21 (5–65) | – | n.s. |
Sex | 41M/13F | 29M/14F | 1.07 (0.4–2.86) | n.s. |
Preceding diarrhea | 26 (48%) | 10 (19%) | 3.06 (1.6–8.2) | <0.02 |
Ventilation | 10 (18%) | 13 (30%) | 0.56 (0.2–1.5) | n.s. |
Sensory deficit at entry | 0 (0%) | 8 (14%) | – | 0.001 |
C. jejuni infections | ||||
Positive C. jejuni serology | 43 (80%) | 12 (28%) | 10.1 (3.6–29.1) | <0.001 |
Positive anti-LOS serology | 47 (87%) | 10 (23%) | 22.1 (6.9–75.5) | <0.001 |
Electrophysiology (N = 64) | ||||
AMAN, AMSAN‡ | 28/42 (67%) | 15/22 (68%) | 0.9 (0.3–3.2) | n.s. |
AIDP§ | 8/42 (19%) | 6/22 (27%) | 0.8 (0.5–1.4) | n.s. |
Unclassified | 6/42 (14%) | 1/22 (5%) | 3.5 (0.4–82.5) | n.s. |
Data were expressed as median or number of patients (percentage); M, male; F, female; CI, confidence interval; – cannot be calculated.
Determined by Chi-square or Fisher’s exact test.
Determined by Wilcoxon-Mann-Whitney U test.
Axonal variants: acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy (AMSAN).
AIDP, acute inflammatory demyelinating polyneuropathy.