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. 2012 Aug 27;7(8):e43976. doi: 10.1371/journal.pone.0043976

Table 2. Clinical characteristics of GBS patients associated with presence IgM and/or IgG antibodies in serum to the gangliosides GM1, GD1a and GQ1b*.

Serum IgM and/or IgG antibodies to GM1, GD1a and/or GQ1b
Positive (N = 54) Negative (N = 43) Odds ratio (95% CI) P-value
Clinical features
Age (median) 18 (2–52) 21 (5–65) n.s.
Sex 41M/13F 29M/14F 1.07 (0.4–2.86) n.s.
Preceding diarrhea 26 (48%) 10 (19%) 3.06 (1.6–8.2) <0.02
Ventilation 10 (18%) 13 (30%) 0.56 (0.2–1.5) n.s.
Sensory deficit at entry 0 (0%) 8 (14%) 0.001
C. jejuni infections
Positive C. jejuni serology 43 (80%) 12 (28%) 10.1 (3.6–29.1) <0.001
Positive anti-LOS serology 47 (87%) 10 (23%) 22.1 (6.9–75.5) <0.001
Electrophysiology (N = 64)
AMAN, AMSAN 28/42 (67%) 15/22 (68%) 0.9 (0.3–3.2) n.s.
AIDP§ 8/42 (19%) 6/22 (27%) 0.8 (0.5–1.4) n.s.
Unclassified 6/42 (14%) 1/22 (5%) 3.5 (0.4–82.5) n.s.
*

Data were expressed as median or number of patients (percentage); M, male; F, female; CI, confidence interval; – cannot be calculated.

Determined by Chi-square or Fisher’s exact test.

Determined by Wilcoxon-Mann-Whitney U test.

Axonal variants: acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy (AMSAN).

§

AIDP, acute inflammatory demyelinating polyneuropathy.