Table 1. Frequency of LTR genotypes in spleen and brain of SIV-infected macaques.
Tissue: | Genotype: | WT | 1–5S | 2–5 | 6–10 | 12–15 | 17–21 | 24–27 | 28–34 | 25–26† | 4–6† | total # of clones |
Spleen | days p.i. | Genotype Frequency (%) | ||||||||||
RNA | 10 | 46 | 31 | 6 | <1 | 17* | 173 | |||||
21 | 5 | 16 | 48 | <1 | 22 | 2 | <1 | 5 | 135 | |||
42 | 3 | 2 | 61 | 4 | 13 | 6 | <1 | 10 | 348 | |||
48–84 | <1 | 62 | <1 | 3 | 29 | 5 | 269 | |||||
Brain | ||||||||||||
DNA | 10 | 71 | 29 | 188 | ||||||||
21 | 34 | 48 | 17 | 158 | ||||||||
RNA | 21 Ŧ | 62 | 34 | 4 | 94 | |||||||
42 | 84 | 2 | 4 | 2 | 8 | 322 | ||||||
48–84 | <1 | 4 | 65 | 2 | 24 | 2 | 3 | 275 |
Summary of genotype frequencies (%) and total number of clones sequenced from spleen and brain at 10 (616, A4P020), 21 (Pzr1, PBc2), 42 (PLc2, PEe2, PFc2, PLB2), and 48–84 (T4363, 01P006, 389) days postinoculation (p.i.). The frequencies and total number of clones sequenced reflects those as shown in Figure 2B and C.
Indicates variant genotype with the absence of both the +123A/G and +146C/A substitution within the DS1 C/EBP site.
Indicates the absence of +123A/G but the presence of +146C/A (DS1C/A) substitution.
Genotype frequency from analysis of brain RNA from macaques PBc2 euthanized at 21 days p.i.