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. 2012 Aug 27;7(8):e43128. doi: 10.1371/journal.pone.0043128

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© 2012 Lowe, Haussler

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) We show the density of genes (blue), all CNEEs (red), just those CNEEs co-opted from mobile elements (green), and mobile elements (gray) windowed over 1 Mb intervals on the q arm of chromosome 16 where there are a number of gene-poor regions. Exaptations are less likely to occur in gene-poor areas when compared to CNEEs in general. (B) The difference between the density of CNEEs and that of exaptations is shown against a schematized backdrop of gene density. CNEEs have a greater normalized density in gene deserts and gene-poor regions of the genome compared to exaptations. In gene deserts, locations in the genome more than 1 Mb from the closest transcription start site, have a depletion of exaptations compared to the number of CNEEs (, hypergeometric test).

Inline graphic — (A) We show the density of genes (blue), all CNEEs (red), just those CNEEs co-opted from mobile elements (green), and mobile elements (gray) windowed over 1 Mb intervals on the q arm of chromosome 16 where there are a number of gene-poor regions. Exaptations are less likely to occur in gene-poor areas when compared to CNEEs in general. (B) The difference between the density of CNEEs and that of exaptations is shown against a schematized backdrop of gene density. CNEEs have a greater normalized density in gene deserts and gene-poor regions of the genome compared to exaptations. In gene deserts, locations in the genome more than 1 Mb from the closest transcription start site, have a depletion of exaptations compared to the number of CNEEs (, hypergeometric test).