Table 2. Mutation frequencies and burden effects in probands.

Gene	Mutations	N (%)		p value
		≥90th	≤10th	C-alpha	CAST	CMC	Fisher's
N sequenced		171	136
LIPG	Total	22 (19.9%)	3 (2.2%)	2.7*10−3	5.5*10−4
	N396S	11 (6.4%)	2 (1.5%)				0.04
	R476W	6 (3.5%)	1 (0.7%)				0.14
CETP	Total	1 (0.6%)	0 (0.0%)				0.55
GALNT2	Total	4 (2.3%)	0 (0.0%)	0.35	0.13
All genes	Total	25 (14.6%)a	3 (2.2%)	2.6*10−3	9.9*10−5	3.0*10−3
	Novel	8 (4.7%)	0 (0.0%)	0.30	9.9*10−3	0.04

^a, Two probands have rare LIPG+GALNT2 variants.