Table 5. Additional mutations in individuals with LIPG mutations and low HDLc.

Gene	Mutation		Novel?	Vertebrate conservation	Predicted effect
	Position (hg18)	Effect
ABCA1	Chr9:106631215 T>A	M640L	No [47]	Completely conserved	Possibly damaging (Polyphen-2)
	Chr9:106619433 C>G	IVS24+1G>C	No [15]	Completely conserved	Abolishes splice donor site (Spliceview)
	Chr9:106618441 G>A	S1181F	No [48]	Completely conserved	Probably damaging (Polyphen-2)
LCAT	Chr16:66534158 G>A	T147I	No [12]	Completely conserved	Possibly damaging (Polyphen-2)
LPL	Chr8:19857809 A>G	N318S	No [13]	Ser tolerated	Reduced HDLc (Reymer et al., 1995)