Table 5. Gene sets from the Molecular Signatures Database (MSigDB) corresponding to 2 of the 5 major collections [56].
Collection | No. gene | Enriched sets | Nominal | FDR | NES |
sets | p-value | q-value | |||
C2 Curated | 3272 | ||||
Canonical Pathways | 880 | mTOR pathway | 0.0 | 0.191 | 1.72 |
Rho pathway | 0.004 | 0.197 | 1.74 | ||
Integration of energy metabolism | 0.008 | 0.219 | 1.783 | ||
Metabolism of proteins | 0.0 | 0.188 | 1.809 | ||
C4 Computational | 881 | ||||
Cancer Modules | 454 | module 159 | 0.002 | 0.148 | 1.61 |
module 273 | 0.002 | 0.158 | 1.62 | ||
module 346 | 0.013 | 0.177 | 1.67 |
Summary of the the GSEA results: some of the enriched gene sets involved in cancer and metabolism are shown (Nom. pval and FDR ).