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. 2012 Aug 27;7(8):e44133. doi: 10.1371/journal.pone.0044133

Table 4. Factors associated with inadequate dosing of pyrazinamide among patients treated with Rifater or pyrazinamide in single-drug preparation, 2007–2010, Taipei.

Adequate Too high Too low
Number (%) Relative RR 95% CI Relative RR 95% CI
Sex
Female 699(82.9%) 1 1
Male 1275(69.6%) 1.00 0.61–1.63 1.98 1.54–2.54
Weight (kg)
≤39 92(77.3%) 1 1
40–49 635(88.1%) 1.09 0.55–2.15 0.13 0.06–0.29
≥50 1247(68.0%) 0.01 0.002–0.05 2.66 1.49–4.75
Preparations
Pyrazinamide 620(75.2%) 1 1
Rifater 1354(73.2%) 0.04 0.02–0.08 2.05 1.63–2.57

Adequate dosage (20–30 mg/kg) as the base for comparison. Too high, >30 mg/kg. Too low, <20 mg/kg. RR, risk ratio. CI, confidence interval.