Table 2. Univariate and multivariate analyses of overall survival of gastric cancer patients.
| Variables | n a | Univariate analyses | Multivariate analyses | ||||
| HR | (95% CI) | P value | HR | (95% CI) | P value | ||
| Age (years) | 0.181 | ||||||
| <55 | 179 | 1.000 | |||||
| ≥55 | 231 | 1.229 | 0.909–1.661 | ||||
| Gender | 0.947 | ||||||
| Female | 140 | 1.000 | |||||
| Male | 270 | 0.990 | 0.727–1.346 | ||||
| Tumor size | <0.001* | 0.635 | |||||
| <3 cm | 63 | 1.000 | 1.000 | ||||
| ≥3 cm | 347 | 4.382 | 2.155–8.910 | 1.198 | 0.567–2.530 | ||
| Tumor infiltration | <0.001* | 0.289 | |||||
| T1 | 47 | 1.000 | 1.000 | ||||
| T2 | 38 | 6.601E3 | 0.000–1.045E34 | 9.683E3 | 0.000–9.369E44 | ||
| T3 | 42 | 2.527E4 | 0.000–3.987E34 | 1.243E4 | 0.000–1.201E45 | ||
| T4a | 221 | 3.482E4 | 0.000–5.487E34 | 1.477E4 | 0.000–1.427E45 | ||
| T4b | 62 | 7.151E4 | 0.000–1.127E35 | 2.067E4 | 0.000–1.997E45 | ||
| Local lymph node metastasis | <0.001* | 0.223 | |||||
| N0 | 137 | 1.000 | 1.000 | ||||
| N1 | 71 | 2.439 | 1.442–4.127 | 0.954 | 0.513–1.776 | ||
| N2 | 73 | 2.941 | 1.764–4.902 | 1.086 | 0.578–2.040 | ||
| N3 | 129 | 5.309 | 3.418–8.248 | 1.438 | 0.787–2.627 | ||
| Distant metastasis | <0.001* | 0.044* | |||||
| M0 | 366 | 1.000 | 1.000 | ||||
| M1 | 44 | 5.379 | 3.731–7.756 | 3.835 | 1.036–14.191 | ||
| TNM staging | <0.001* | 0.052 | |||||
| 1 | 52 | 1.000 | 1.000 | ||||
| 2 | 142 | 14.990 | 2.055–109.348 | 3.789 | 0.444–32.355 | ||
| 3 | 169 | 41.842 | 5.835–300.059 | 7.440 | 0.808–68.514 | ||
| 4 | 47 | 121.343 | 16.657–883.966 | 5.403 | 0.401–72.805 | ||
| AHRR | <0.001* | 0.004* | |||||
| Low | 175 | 1.000 | 1.000 | ||||
| High | 235 | 0.482 | 0.357–0.650 | 0.635 | 0.464–0.868 | ||
HR, hazard ratio;
CI, confidence interval;
a
Numbers of cases in each group;
*
Statistically ignificant (P<0.05).