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Systemic and regional vascular effects of aliskiren in wild-type mice. MBP and total peripheral, renal, and coronary resistance were measured in anesthetized wild-type mice (n=6–7/group) using the fluorescent microsphere technique. Animals received saline or aliskiren (ALK, 1 mg/kg, i.v. bolus followed by an infusion 10 μg/kg/min). Data are means ± se. *P < 0.05 vs. saline.
