Table 2.
Pathological and bacteriological findings at postmortem in vaccinated and control goatsa
| Group | Lungs |
LN |
|||
|---|---|---|---|---|---|
| Vol of VL (cm3) | Vol of VL/lung vol (%) | No. of lobes with VLb | Vol of VL (cm3) | Bacterial load (log CFU) | |
| BCG | 80 (44–157) | 8.1 (4–13.5) | 2/7 (1–3/7) | 0.2 (0–4.1)* | 3.7 (2.6–4.3)* |
| BCG-Ad | 4 (0–22)** | 0.5 (0.1–1.8)** | 1.9/7 (1.4–2.5/7) | 0.1 (0–0.2)** | 3.2 (2.3–3.9)** |
| Control | 36 (27–94) | 3.8 (2.4–8.1) | 3.4/7 (2.3–4.4/7) | 6.1 (2.3–30.1) | 4.5 (4.3–4.9) |
a
The volumes of visible lung lesions were calculated using multidetector computed tomography and those for lymph nodes (LN) by direct visual observation. Values are medians; interquartile ranges are in parentheses. Significant differences between groups are shown as follows: ∗, P < 0.005; ∗∗, P < 0.001 (Kruskal-Wallis test with the post hoc Mann-Whitney test).
b
Values are means.