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. Author manuscript; available in PMC: 2013 Aug 24.
Published in final edited form as: Biochem Biophys Res Commun. 2012 Jul 22;425(2):189–194. doi: 10.1016/j.bbrc.2012.07.064

Figure 2. Tmeff2-KO mice have structurally normal central, peripheral and enteric nervous system as revealed by AP-staining.

Figure 2

A. Representative sagittal sections of the head from Tmeff2PLAP/+ (+/−) and Tmeff2-KO (−/−) embryos (E12.5) stained for PLAP activity.

B. Representative coronal sections of brains from P15 control (+/−) and Tmeff2-KO (−/−) mice stained for PLAP activity showing similar staining patterns.

C. Representative coronal sections of spinal cord from control (+/−) and Tmeff2-KO (−/−) mice showing Tmeff2 expression in spinal cord, dorsal root ganglion (arrows), and sympathetic ganglion (arrowheads). No difference in staining patterns was observed between control and mutant mice.

D. Representative coronal sections of whiskers from control (+/−) and Tmeff2-KO (−/−) mice stained for PLAP activity showing similar innervation patterns.

E. Representative images of PLAP-stained stomach sections from heterozygous control (+/−) and Tmeff2-KO (−/−) mice.

F. Representative images of PLAP-stained intestinal sections from control (+/−) and Tmeff2-KO (−/−) mice. Upper panels, large intestines; lower panels, small intestines.

Scale bars: A, B 200µm. C, D, E, F 100µm.