Table 4.

Multivariate-adjusted odds ratios of the cross-classification of the intervention and changes in weight over one year and elimination of vasomotor symptoms (VMS) among 6,104 postmenopausal women with VMS at baseline

	N	Elimination of VMS	MV-adjusted OR†	95% CI
Any VMS at baseline
Weight change (%) and study arm
Gain ≥ 10%, Controls	87	19	0.78	(0.46–1.31)
Gain ≥ 10%, Intervention	37	11	1.27	(0.61–2.63)
Gain >7-<10%, Controls	583	145	0.89	(0.72–1.10)
Gain >7-<10%, Intervention	42	16	1.75	(0.92–3.33)
Gain >3-7%, Controls	101	27	1.08	(0.68–1.70)
Gain >3-7%, Intervention	202	49	0.99	(0.70–1.39)
Maintain within 3%, Controls	2,160	593	1.00
Maintain within 3%, Intervention	1,070	311	1.15	(0.97–1.35)
Loss >3-7%, Controls	514	160	1.17	(0.95–1.45)
Loss >3-7%, Intervention	626	199	1.16	(0.96–1.41)
Loss >7-<10%, Controls	121	34	1.07	(0.71–1.63)
Loss >7-<10%, Intervention	268	91	1.26	(0.96–1.65)
Loss ≥ 10%, Controls	106	36	1.40	(0.92–2.13)
Loss ≥ 10%, Intervention	187	80	1.89	(1.39–2.57)

^*p-value, continuous variable

^**Age-adjusted model adjusted for age (continuous).

^†Multivariate-adjusted models were adjusted for age (continuous), ethnicity (White (ref), Black, Hispanic, Asian, Indian, other), education (≤HS, ≤ college, graduate school (ref)), years since menopause (0-<10, 10-<20, 20+ (ref)), depressive symptoms (no (ref), yes), physical activity (0, >0-5, >5-10, >20-15, >15 METS/wk (ref)), alcohol intake (0 (ref), >0-0.5, >0.5-2, >2 svg/wk), smoking (never (ref), past, current). Models were also simultaneously adjusted for DM arm (intervention, control (ref)) and weight change (percent change categories used in intervention analyses).