. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Nat Rev Cancer. 2012 Aug 17;12(9):639–648. doi: 10.1038/nrc3320

Table 1.

Functional classes of retroviral oncoproteins

Functional class	Representative example	Source virus
Growth factor	Sis, platelet-derived growth factor	Simian sarcoma virus
Receptor tyrosine kinase	ErbB, epidermal growth factor receptor	Avian erythroblastosis virus
Hormone receptor	ErbA, thyroid hormone receptor	Avian erythroblastosis virus
G-protein	H-Ras, GTPase K-Ras, GTPase	Harvey sarcoma virus Kirsten sarcoma virus
Adaptor protein	Crk, modular signaling link	CT10 avian sarcoma virus
Non-receptor tyrosine kinase	Src, signaling protein kinase Abl, signaling protein kinase	Rous sarcoma virus Abelson murine leukemia virus
Serine-threonine kinase	Akt, signaling protein kinase Mos, signaling protein kinase	Akt8 murine thymoma virus Moloney murine sarcoma virus
Transcriptional regulator	Jun, component of the AP-1 (activator protein 1) complex Fos, component of the AP-1 (activator protein 1) complex Myc, transcription factor	Avian sarcoma virus 17 Finkel-Biskis-Jinkins murine sarcoma virus Avian myelocytomatosis virus MC29
Lipid kinase	Pi3k, phosphatidylinositol 3-kinase	Avian sarcoma virus 16