Figure 2. Time-dependent inhibition effect of Celecoxib on IL-1ß induced collagen degradation by corneal fibroblasts.

Cells were cultured in collagen gels for the indicated times in the presence of plasminogen 60µg/mL and in the absence (open symbols) or presence of 0.1ng/mL IL-1ß (close symbols), in the absence (circles) or presence (squares) of 10µmol/L Celecoxib, after which the amount of degraded collagen was determined. Data are mean±SEM of values from three experiments. ^bP< 0.001 (Dunnett test) vs the corresponding value for cells cultured with IL-1 ß and plasminogen.