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. 2012 Jun 6;65(8):397–404. doi: 10.1038/ja.2012.43

Figure 1.

Figure 1

Plasma and blood concentrations over time. (a) Plasma concentration for seven salicylidene acylhydrazides administered intraperitoneally in two cassettes (each compound 15–19 μg, 0.7–1 mg kg−1) to two mice per cassette. Filled symbols represent compounds in cassette 1 and open symbols cassette 2. ME0053 was included in both cassettes. Blood samples were collected 10, 30, 45, 60, 90 and 240 min after administration of compounds. Blood concentrations over time for (b) ME0177 after 1 mg (52–60 mg kg−1) dose and for (c) ME0192 after 0.5 mg (28–30 mg kg−1) dose administered intraperitoneally to seven mice per compound. Five mice were sampled at each time point, 10, 30, 60, 120, 180, 240, and 300 min after administration for ME0177 and 10, 30, 60, 120, 240, 480 and 720 min after administration of ME0192.