Table 2. Calculated pharmacokinetic parameters (mean±s.d.) after intraperitoneal administration of ME0177 (1 mg, 55–60 mg kg−1) and ME0192 (0.53 mg, 28–30 mg kg−1).
| Pharmacokinetic parameter | ME0177 | ME0192 |
|---|---|---|
| t1/2 (h) | 0.66±0.08 | 5.04±1.06 |
| Tmax (h) | 0.26±0.15 | 1.36±0.58 |
| Cmax (μg ml−1) | 17.08±5.5 | 0.24±0.05 |
| AUC 0-inf_obs (μg ml−1 h) | 12.80±3.5 | 2.15±0.27 |
| MRT 0-inf_obs (h) | 0.75±0.14 | 7.39±1.63 |
| Vz/F_obs ((μg)/(μg ml−1)) | 80.99±25.6 | 2046.13±424.28 |
| Cl/F_obs ((μg)/(μg ml−1) h−1) | 86.17±29.9 | 283.12±37.15 |