Table 3. The inhibitory effect of ME0192 is not reduced by pre-incubation of the compound in vaginal fluid simulant (VFS) at pH 4.5–6.5. Number of C. trachomatis inclusion forming units (IFU) are indicated in the table.
| Experiment | Compound | No simulant | VFS pH 4.5 | VFS pH 5.5 | VFS pH 6.5 |
|---|---|---|---|---|---|
| 1 | Vehicle | 3 509 000 | 3 908 300 | 3 920 400 | 4 428 600 |
| ME0192 | 240 | 40 | 30 | 80 | |
| 2 | Vehicle | n/a | 5 239 700 | n/a | 3 683 800 |
| ME0192 | 40 | 40 | |||
| ME0192 | 20 | 40 |
Abbreviation: n/a, not available.