Table 1.
Clinical history, MRI findings, pathological diagnosis, and postoperative outcome of 10 patients who underwent selective amygdalohippocampectomy.
| Case no. | Age/sex | MRI findings | Pathological diagnosis of hippocampus | AED medication | Type of seizures | Years with epilepsy | No. seizures/month |
|---|---|---|---|---|---|---|---|
| 1a, b, c | 21/M | MTS, left | mild gliosis, focal neuronal loss | LTG, LEV | SPS, CPS | 19 | 30 |
| 2 a, b, c | 26/F | MTS, right | mild gliosis, severe neuronal loss | CBZ, GP, LEV | CPS, SGS | 10 | 8 |
| 3 a, b, c | 28/F | MTS, left | marked gliosis, severe neuronal loss (Wyler II)f | OXC, LTG, PHT | SPS, CPS, SGS | 26 | 2 |
| 4 a, b, c | 27/M | MTS, right | marked gliosis, severe neuronal loss (Wyler II) | LTG, LEV | CPS, SGS | 25 | 4 |
| 5 a, b, c | 34/F | MTS, left | marked gliosis, severe neuronal loss (Wyler III) | LEV, PB | SPS, CPS, SGS | 32 | 6 |
| 6 b, c | 40/F | MTS, left | marked gliosis, focal mild neuronal loss | VPA, LEV | CPS, SGS | 18 | 12 |
| 7 b, c | 68/F | MTS, right | marked gliosis, severe neuronal loss | LTG, LEV | SPS, CPS | 43 | 4 |
| 8 b, c | 22/M | MTS, right | marked gliosis, severe neuronal loss (Wyler IV) | CBZ, GP, LEV | SPS, CPS, SGS | 18 | 4 |
| 9 d, e | 41/M | MTS, right | marked gliosis, severe neuronal loss (Wyler IV) | CBZ, VPA, TPM | SPS, CPS, SGS | 6 | 2 |
| 10 d, e | 41/F | MTS, left | marked gliosis, severe neuronal loss | CBZ, LEV, PHT | SPS, CPS, SGS | 20 | 2 |
AEDs: antiepileptic drugs; CBZ: carbamazepine; LEV: levetiracetam; LTG: lamotrigine; PHT: phenytoin; TPM: topiramate; GP: gabapentin; PB: phenobarbital; OXC: oxcarbazepine; VPA: valproic acid.
SPS: simple partial seizures; CPS: complex partial seizures; SGS: secondary generalized seizures.
aImmunohistochemistry.
bOne-cycle target labelling gene array.
cQuantitative real-time RT-PCR (TaqMan).
dBrain-derived microvascular endothelial cells (MVECs).
eTwo-cycle target labeling gene array.
fWyler classification was not determined in all cases.
MTS, mesial temporal sclerosis.