Table 1.
Patient demographic and cytogenetic data
| Type | Cytogenetics | Cases | M/F | Agea | ZAP70 expressionb | Associated abnormalities |
|---|---|---|---|---|---|---|
| T-ALL |
|
11 |
6/5 |
44.7; (19-56) |
0.363; 0.252; (0.090-2.955) |
9p abnormality(n = 5) 6q deletion (n = 2 t(10;14) (n = 1) |
| B-ALL |
|
65 |
36/29 |
46.0; (18-79) |
0.332; 0.185; (0.002-5.360) |
|
| B-ALL |
t(9;22) |
18 |
10/8 |
44.4; (23-70) |
0.440; 0.191; (0.010-5.360) |
Hyperdiploid (n = 2), Monosomy 7 (n = 2) 9p abnormality (n = 3) 12p gain (n = 2) t(1;19) (n = 1) |
| B-ALL |
t(1;19) TCF3-PBX1 |
3 |
2/1 |
43.3; (42-52) |
0.219; 0.210; (0.193-0.254) |
9p abnormality (n = 2) 6q deletion (n = 2) |
| B-ALL |
9p abnormality |
12 |
8/4 |
45.2; (18-72) |
0.180; 0.176; (0.004-0.535) |
Monosomy7 (n = 2) RUNX1 (n = 2) 12p abnormality (n = 3) 6q deletion (n = 2) |
| B-ALL |
Burkitt lymphoma |
6 |
3/3 |
44.7; (22-78) |
0.159; 0.168; (0.005-0.350) |
12p abnormality (n = 1) 9p abnormality (n = 2) |
| B-ALL |
Hyperdiploid |
6 |
5/1 |
45.9; (22-76) |
0.232; 0.184; (0.004-1.383) |
|
| B-ALL |
Monosomy 7 |
4 |
1/3 |
44.9; (37-58) |
0.177; 0.182; (0.015-0.399) |
12p abnormality (n = 1) |
| B-ALL |
Hypodiploid |
3 |
1/2 |
43.7; (18-79) |
0.173; 0.182; (0.067-0.290) |
12p abnormality (n = 1) |
| B-ALL |
MLL/AFF1 |
1 |
1 |
30.0 |
0.089 |
12p abnormality |
| B-ALL | Normal 46, XX or 46, XY | 12 | 6/6 | 46.7; (18-82) | 0.140; 0.100; (0.002-0.291) |
a Mean patient age in years (range).
b ZAP70 RNA expression was quantified by RT-qPCR and the normalised values expressed relative to that seen in Jurkat control cells. Data shown are mean, median and range for each sub-group.